Current Issue : January - March Volume : 2020 Issue Number : 1 Articles : 6 Articles
Ascorbic acid (vitamin C) is a water-soluble vitamin and a recognized antioxidant drug that\nis used topically in dermatology to treat and prevent the changes associated with photoaging, as well\nas for the treatment of hyperpigmentation. Ascorbic acid has neutralizing properties of free radicals,\nbeing able to interact with superoxide, hydroxyl and free oxygen ions, preventing the inflammatory\nprocesses, carcinogens, and other processes that accelerate photoaging in the skin. Current research\nfocuses on the search for stable compounds of ascorbic acid and new alternatives for administration\nin the dermis. Unlike plants and most animals, humans do not have the ability to synthesize our own\nascorbic acid due to the deficiency of the enzyme L-gulono-gamma-lactone oxidase, which catalyzes\nthe passage terminal in the ascorbic acid biosynthesis. To deal with this situation, humans obtain this\nvitamin from the diet and/or vitamin supplements, thus preventing the development of diseases and\nachieving general well-being. Ascorbic acid is involved in important metabolic functions and is vital\nfor the growth and maintenance of healthy bones, teeth, gums, ligaments, and blood vessels. Ascorbic\nacid is a very unstable vitamin and is easily oxidized in aqueous solutions and cosmetic formulations.\nAscorbic acid is extensively used as an ingredient in anti-aging cosmetic products, as sodium ascorbate\nor ascorbyl palmitate. This review discusses and describes the potential roles for ascorbic acid in skin\nhealth and their clinical applications (antioxidative, photoprotective, anti-aging, and anti-pigmentary\neffects) of topical ascorbic acid on the skin and main mechanisms of action. Considering the instability\nand difficulty in administering ascorbic acid, we also discuss the importance of several factors\ninvolved in the formulation and stabilization of their topical preparations in this review....
Sunflower oil meal is one of the abundantly available by-product outcome of the sunflower edible oil separation industry. Sunflower meal has a very low economic value despite being a natural available source of skincare beneficial antioxidants. In this study the main objective was extraction of antioxidant, purification of antioxidant by column chromatography and then utilizing it to formulate antioxidant rich skincare cosmeceutical product. Cosmeceutical product formulated will not only nourish the skin but also make it healthy due to the antioxidants present. LCMS analysis of the Ethanol extract confirms the predominant phenol compound was chlorogenic acid and caffeic acid, various phenolic acids were also identified. DPPH study suggests the extracted antioxidant has good radical scavenging activity 54.64%. An important study estimated benefit of developed cosmeceutical formulation was the quality assurance of the skincare cream by deciding the chemical, physical, subjective clinical trials and pharmacological characteristics....
The aim of this study was to develop a phytocosmetic sunscreen emulsion with antioxidant\neffect, containing a blend of flavonoid-enriched plant extracts. In vitro sun protection factor,\nantioxidant activity, skin irritation, photostability, cutaneous permeation, and retention of flavonoids\nwere evaluated. Thermodynamically stable emulsions were obtained and tested for sensorial\nanalysis after loading the blend of extracts. The selected emulsion was stable when stored at\nlow temperatures (5 Degree C), for which after 120 days the concentration of quercetin and rutin were\nabove their limit of quantification���.\n .....
A green ultrasound-assisted extraction (UAE) method using glycerol/water mixtures\nfor extraction of licorice (Glycyrrhiza glabra) bioactive constituents was developed in this study.\nThe response surface method, according to the Box-Behnken design, was employed to optimize the\nextraction parameters: glycerol concentration (X1), temperature (X2), and the amount of herbal drug\nused in the production (X3). The responses were content of total phenols (TP), TP extraction efficiency\n(TPy) and the content of licorice characteristic constituents, glabridin (Gla) and isoliquiritigenin (Iso).\nResponse surface analysis predicted the optimal extraction conditions for maximized amounts of\nTP, Tpy, Gla, and Iso. The extracts were prepared using the calculated conditions. The analysis of\nthe selected constituents confirmed the validity of the model. Furthermore, biological activity of the\nextracts was tested. The results demonstrate that UAE using glycerol is a fast and efficient method\nfor preparation of extracts with excellent radical scavenging, Fe2+ chelating and antioxidant activity.\nFurthermore, the observed notable tyrosinase and elastase inhibitory activity of the extracts, as well\nas their anti-inflammatory activity, indicate the anti-aging properties of the investigated extracts.\nThe fact that the extracts were prepared using the safe, cosmetically active solvent, glycerol, makes\nthem suitable for direct use in specialized cosmeceutical formulations....
The phenol content of vegetable oil and its antioxidant activity are of primary interest for\nhuman health. Oilseed species are considered important sources of these compounds with medicinal\neffects on a large scale. Total phenol content (TPC) and antioxidant activity (AA) of safflower oil\nwere previously studied. Nevertheless, there is no report on genotypic differences and antiaging\nactivity of safflower oil. The aim of this study was to determine the TPC, diphenyl-picrylhydrazyl\n(DPPH), and antiaging activity on three respective accessions from Syria, France, and Algeria of\nseed oil of safflower grown under semi-arid conditions during 3 consecutive years (2015, 2016, and\n2017). The results showed that phenol content as well as antioxidant and antiaging activity varied\naccording to both genotype and years. In 2017, the mean value of TPC in oil seed was two times\nhigher than in 2015 and 2016. Moreover, accessions presented different TPC values depending on\nthe year. The highest antioxidant activity was observed among accessions in 2017 compared to\n2015 and 2016. As expected, a positive correlation was found between TPC and antioxidant activity.\nThe inhibition in the collagenase assay was between 47% and 72.1% compared to the positive control\n(83.1%), while inhibition in the elastase assay of TPC ranged from 32.2% to 70.3%, with the positive\ncontrol being 75.8%. These results highlight the interest of safflower oil as a source of phenols with\nvaluable antioxidant and antiaging activity, and uses for cosmetics....
The development of functional cosmetics with skin improvement effects from natural\nsources is necessary. In this study, the antioxidant, antiwrinkling, moisturizing, and whitening effects\nof Gardeniae fructus extract (GF) were investigated in keratinocytes, melanocytes, and fibroblast cells.\nAntioxidant activity was determined by a DPPH free radical scavenging assay. MMP-1, MMP-9,\nHAS1, and filaggrin mRNA levels were measured by RT-PCR in keratinocytes and fibroblast cells.\nMITF and tyrosinase protein levels were evaluated by blotting analysis in melanocytes. DPPH free\nradical activity was investigated to determine whether GF showed dose-dependent inhibitory activity.\nGF induced the upregulation of HAS1 and filaggrin mRNA expression in keratinocytes and fibroblast\ncells. GF led to the downregulation of MMP mRNA levels in keratinocytes and fibroblast cells.\nWestern blotting was performed to confirm the whitening-related protein (MITF and tyrosinase)\nlevels induced by GF in melanocytes, and the inhibitory activity was superior to that of the Alpha-MSH\nused for the comparison test. GF showed marked antioxidant, antiwrinkling, skin moisturizing, and\nwhitening activity in keratinocytes, melanocytes, and fibroblast cells. Through the results of these\nexperiments, the applicability of GF as a natural and functional cosmetic material was verified....
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